First Plasma Fractionation in Iran sets back to 1976 by Iranian Blood Transfusion Organization (IBTO). In 1990, Ministry of Health and Medical Education decided to establish a blood fractionation company for supplying plasma products in Iran. Finally, in 1994, Iranian Blood research and fractionation center started to work as only Plasma fractionation and distributer of Plasma drive products. In 1999 the center transformed to a Company with 80000 plasma fractionation in year for manufacturing plasma drive products, Anti serums and blood group diagnostic Kits. Reconstruction to increase production capacity and updating Virus inactivation methods begun in 2003 and continues until today.